An efficient method for nucleophilic aromatic substitution of 2-chloroquinoline-3-carbaldehydes
is described for the synthesis of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes. The protocol
involves the effective use of phase transfer catalyst CTAB in combination with polyethyleneglycol-400
to obtain the desired products in less reaction time. The newly developed method is found superior
to the previously reported methods due to easy work up and excellent yields.
Keywords
quinoline, nucleophilic aromatic substitution, phase transfer catalyst, CTAB, piperidine.