CHIANG MAI UNIVERSITY JOURNAL OF NATURAL SCIENCES

Volume 18, No. 03, Month JULY, Year 2019, Pages 393 - 407

Evaluation of anti-inflammatory, analgesic, and antipyretic activities of pseuderanthemum palatiferum

Kannika Inchab, Parirat Khonsung, Natthakarn Chiranthanut, Puongtip Kunanusorn, Ampai Panthong, and Seewaboon Sireeratawong

Abstract Download PDF

The objectives of this study were to evaluate the anti-inflammatory, analgesic, and antipyretic activities of water extract from fresh leaves of Pseuderanthemum palatiferum (WEPP).The anti-inflammatory activity of WEPP was evaluated in ethylphenylpropiolate (EPP)-induced ear edema, carrageenan-induced paw edema, arachidonic acid (AA)-induced paw edema, and cotton pellet-induced granuloma experiments. Acetic acid-induced writhing and tail-flick experiments were conducted to evaluate analgesic activity. Finally, antipyretic activity was evaluated in yeast-induced hyperthermia model. WEPP showed the anti-inflammatory activity and the analgesic activity but without antipyretic property. WEPP (2 mg/ear) significantly inhibited edema thickness induced by EPP (75%). Oral administration of WEPP (600 mg/kg) significantly inhibited paw edema induced by carrageenan (57%), and arachidonic acid (47%). WEPP (600 mg/kg) did not significantly reduce the transudative weight, granuloma weight, and alkaline phosphatase activity in cotton pellet-induced granuloma formation model. The anti-inflammatory property of WEPP demonstrated on the acute phase and not on the chronic phase of inflammation. WEPP oral administration (150, 300, and 600 mg/kg) significantly reduced the writhing response induced by acetic acid by 21%, 57%, and 79%, respectively. In tail-flick test, WEPP slightly increased the reaction time of rats (25%). The analgesic activity of WEPP may act via peripheral pathway. The antipyretic effect of WEPP (600 mg/kg) was not observed in yeast-induced hyperthermia model. WEPP displays an anti-inflammatory effect and has a prominent analgesic effect on the peripheral system.

Keywords

Pseuderanthemum palatiferum, Anti-inflammation, Analgesic, Acetic acid, Tail-flick, Antipyretic

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