CHIANG MAI UNIVERSITY JOURNAL OF NATURAL SCIENCES

Volume 19, No. 01, Month JANUARY, Year 2020, Pages 61 - 75

Environmentally friendly and facile synthesis of 2-oxo- and thioxo-1,2,3,4-tetrahydropyrimidines catalyzed by formic acid as a natural green and bio-based catalyst under solvent-free conditions

Farzaneh Mohamadpour

Abstract Download PDF

A green synthetic route to the facile Biginelli synthesis of 2-oxo- and thioxo-1,2,3,4-tetrahydropyrimidines have been developed using formic acid as a natural green and bio-based catalyst under solvent-free reaction conditions. All reactions are completed in a short period of times and the products are obtained in high to excellent yields. The salient features of this green approach are simple work-up with no necessity of chromatographic purification steps, absence of hazardous organic solvents, use of safe, non-volatile, noncorrosive and readily green catalyst, solvent-free conditions, one-pot reaction, eco-friendly and clean synthesis.

Keywords

Formic acid, Natural green and Bio-based catalyst, 2-oxo- and Thioxo-1,2,3,4-tetrahydropyrimidines, Solvent-free conditions

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