SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY

Volume 42, No. 06, Month NOVEMBER, Year 2020, Pages 1171 - 1186

Proniosomes an effective carrier for dermal and transdermal delivery

Boontida Morakul and Varaporn Buraphacheep Junyaprasert

Abstract Download PDF

Proniosomes are non-ionic surfactant based vesicles that can be hydrated to yield an aqueous niosomal dispersion. The evolution of proniosomes has been motivated by development of niosomes to minimise the stability problems of niosomes and liposomes. Moreover, proniosomes can encapsulate both hydrophilic and lipophilic drugs. They are effective in enhancing skin penetration for transdermal delivery. This article describes key compositions of a proniosomal system, types of proniosomes, preparation techniques, and their characteristic properties including particle size, morphology, flow ability, entrapment efficiency, drug release, and permeability performance. The advantages of proniosomes, the mechanism of action in skin penetration, and the toxicity of proniosomes are discussed. Several categories of drugs formulated for a proniosomal system and topical or transdermal delivery are also reviewed.

Keywords

proniosomes, dermal delivery, transdermal delivery, application

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