SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY

Volume 42, No. 06, Month NOVEMBER, Year 2020, Pages 1304 - 1309

Microwave-assisted extraction of dendrobium nobile lindl. and its ?-glucosidase inhibitory activity.pdf

Chattarika Pengdee , Boonchoo Sritularak and Waraporn Putalun

Abstract Download PDF

Diabetes mellitus (DM) is an important metabolic disease due to its worldwide increasing prevalence. Dendrobium nobile Lindl. is used in traditional Chinese medicine and has been reported to have antidiabetic activity. In this study, several extraction methods, including microwave-assisted extraction (MAE), were applied to D. nobile and the extracts were investigated for α-glucosidase inhibition potency. The optimal MAE conditions maximizing α-glucosidase inhibition were 540 W power, 60 sec extraction time, 40 mL/g solvent-to-feed ratio, and three extraction cycles. Our results show that MAE of D. nobile gave stronger inhibition of α-glucosidase with lower IC50 and faster extraction than the other extraction methods. IC50 of D. nobile extract was related to phenolic content with correlation -0.878, indicating that phenolics were the active compounds inhibiting α- glucosidase in these plant extracts.

Keywords

Dendrobium nobile, microwave-assisted extraction, Taguchi, ?-glucosidase inhibitory activity

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