SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY

Volume 42, No. 02, Month MARCH, Year 2020, Pages 284 - 291

Anti obesity potential of glutinous black rice bran extract anti adipogenesis and lipolysis induction in 3t3-l1 adipocyte model

Warathorn Chumchoochart and Khaetthareeya Sutthanut

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An ethanolic glutinous black rice bran extract (RBE) was prepared and used in the experiments to determine the phenolic and flavonoid contents, antioxidation using DPPH and TBARS assay, anti-adipogenesis, and lipolysis induction in a 3T3-L1 pre-adipocyte model to discover its anti-obesity potential. The results showed that RBE was composed of phenolics, flavonoids, and anthocyanins and showed antioxidative activities (8.58±0.14 mg Vit C eq/g extract and 6.06±0.49 mg BHT eq/g extract). Interestingly, its anti-obesity potential was demonstrated in the interruption of the adipocyte life cycle, i.e. a significant anti-adipogenesis effect in the reduction of lipid accumulation (50.86±3.26 to 97.06±8.09% of the negative control, and triglyceride content in 3T3-L1 pre-adipocytes (36.89±2.08 to 90.56±0.67% of the negative control), and lipolysis induction (relative glycerol content 117.62±1.44 and 163.72±10.18% of control). Therefore, implementation into obesity therapy requires further research.

Keywords

anti-obesity, anti-adipogenesis, lipolysis induction, antioxidation, glutinous black rice bran

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