SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY

Volume 42, No. 02, Month MARCH, Year 2020, Pages 305 - 313

Safety and efficacy assessment of skin gel containing nanoemulsion of phyllanthus emblica extract a randomized, double blind placebo controlled study

Bungorn Sripanidkulchai, Rungsiri Chaiittianan, Khaetthareeya Suttanut

Abstract Download PDF

A skin gel containing a nanoemulsion of Phyllanthus emblica branch extract (emblica nanogel) was tested for its safety and efficacy in a randomized, double-blind, placebo-controlled clinical trial. The patch skin irritation test showed that neither the emblica nanogel nor the placebo nanogel caused skin erythema. The subjects receiving emblica nanogel had a significantly lower melanin index of the cheek at weeks 2, 4, 6, and 8, of the forehead at weeks 4, 6, and 8, and of the forearm at week 8 compared to the placebo group. Skin elasticity was observed to increase for the cheek at week 4, forehead at week 6, and there was no change for the forearm. The levels of skin moisture and erythema of the subjects were not significantly different from the base line levels. In conclusion, the application of emblica nanogel resulted in significant skin whitening during the 8 weeks of application.

Keywords

skin whitening, emblica, nanoemulsion, randomized double-blind, clinical trials, melanin index

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