In this work, a facile, metal-free and efficient protocol for the synthesis of thiazolo- and benzothiazolo[3,2-
a]pyrimidine-6-carboxylate derivatives using onion peel as catalyst is described. For the first time, the onion peels are used for
the synthesis of thiazolo- and benzothiazolo[3,2-a]pyrimidine-6-carboxylate derivatives. The current protocol has numerous
advantages, including cost-effectiveness, avoiding the use of external acids and bases, and the high porosity of the natural
catalyst has led to the desired products in good to excellent yields. We anticipate that this environmental friendly catalyst
presented here will be of great utility in both research institution and industry.
Keywords
onion peel, thiazolo and benzothiazolo-[3,2-a]pyrimidine, metal-free synthesis, heterocyclic compounds
SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY
Published by : Prince of Songkla University Contributions welcome at : http://rdo.psu.ac.th
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