SONGKLANAKARIN JOURNAL OF SCIENCE & TECHNOLOGY

Volume 41, No. 01, Month JANUARY, Year 2019, Pages 229 - 236

In silico simulation and analysis of human p53 and non-human translationally controlled tumor protein

Tanate Panrat, Hirun Saelim, Imran Parvez, Amornrat Phongdara

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Translationally controlled tumor protein (TCTP) is a highly conserved protein found in various organisms and eukaryotes and is broadly expressed in several tissues. TCTP plays a key role in preventing apoptosis and promoting cell survival. The conserved tumor suppressor p53 is a transcription factor which responds to stress signals. p53 controls apoptosis through a series of quantitative and qualitative events which require several binding partners including TCTP. However, the exact coordination of these two molecules in the apoptosis pathway is not clearly understood. In this study, docking simulation successfully identified the binding sites of “human TCTP and human p53”, “Crustacean, Penaeus monodon TCTP and human p53”, and “plant, Elaeis guineensis TCTP and human p53” with binding energies of -843.10 Kcal/mol, -747.80Kcal/mol, and - 786.80 Kcal/mol, respectively. The results implied that non-human TCTPs have less binding activities with human p53 and they are not effective partners compared with human TCTP.

Keywords

apoptosis, interaction mechanism analysis, molecular docking

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